Emerging evidence indicates that specific switches from utilization of one substrate to another can have protective or permissive roles in disease pathogenesis.
Because Tsps interact with other Itg ligands (e.g., Lam, Col, Fn) in vitro it has been debated as to whether Tsps play instructive or merely permissive roles in ECM organization and cell-ECM interactions (Narouz-Ott et al., 2000; Södersten et al., 2006; Tan and Lawler, 2009).
Taken together, our observations add to the growing evidence that PSA-NCAM plays permissive role for neuronal-glial remodeling and further suggest a functional link between activity dependent structural remodeling in GnRH neurons.
Our results suggest that 5-HT1B receptors may play a permissive role in the development, but not expression, of behavioral sensitization, as well as in the acute locomotor response to amphetamine in mice.
Therefore, T-cell-mediated activation of Wnt signaling in osteoblastic cells plays a key permissive role in the mechanism by which iPTH increases bone strength, suggesting that T cell osteoblast crosstalk pathways may provide pharmacological targets for bone anabolism.
In fact, in the RVM there are three functional cell classes: the ON cells (inhibited by opioids) which facilitate nociception, the OFF cells (excited by opioids) which inhibit nociception, both non-serotonergic (but at least a proportion of ON cells are likely to contains 5-HT), and a population of serotonergic cell unresponsive to noxious stimulation and opioids, which may play a permissive role.
Our results provide new insights regarding the orchestration of sleep regulation by 5-HT release, and strongly suggest that Type-2 neurons could play a permissive role, whereas Type-1 neurons could have an executive role in sleep induction and maintenance.
In vitro study revealed that AMPK activation using AICAR or mTOR inhibition using rapamycin effectively negated the beneficial cardiomyocyte mechanical effects of TLR4 inhibition (CLI-095) against paraquat toxicity, supporting a permissive role for AMPK-mTOR in TLR4 inhibition-offered cardioprotection against paraquat.
Interestingly, this effect is consistent with auxin's permissive role in cell division.
Whether EMH plays a required or permissive role in myeloproliferative disorders (MPDs) is unknown.
It remains to be seen whether precuneal activity plays a similarly permissive role in patients with focal epilepsy and complex partial seizures, i.e. periods of impaired consciousness.
