Sentence examples for permissive milieu from inspiring English sources

In contrast, the administration of a mixture of physiologically relevant cytokines and growth factors as by EPC-CM injection, might induce a permissive milieu for differentiated as well as progenitor cells of the host and thus stimulate the endogenous repair system [43] [45].

The neural precursor cells (NPCs) must be located in neurogenic niche, a permissive milieu, which maintain their constant ability to divide and form mature neurons even in the adult brain.

As lipid rafts are known to be enriched in PI 4,5 P2 and PI 3,4,5 P3, they provide a permissive milieu for the interaction between PDK1 and Akt.

By suppressing interferon-gamma expression and release from antigen-specific T cells, and locally enhanced IL-4 and IDO levels COX-2 may contribute to a tumor-permissive milieu.

Cancer is largely caused by the summation of activated oncogenes and inactivated tumor-suppressors that occur in a permissive epigenetic milieu resulting in various pathologic features: autonomous proliferation, immortalization, blocked differentiation, the induction of angiogenesis, capacity for invasion, resistance to apoptosis and genomic instability [1].

While initially increasing macrophage microbicidal activity, ROS rapidly induces necroptosis during Mtb infection, resulting in the release of mycobacteria into the growth-permissive extracellular milieu (Galluzzi and Kroemer, 2008; Roca and Ramakrishnan, 2013; Wang et al., 2012).

In active human TB, granulomas can progress to central necrosis caused by lysis of the infected macrophages that releases viable mycobacteria into a growth-permissive extracellular milieu (Pagán and Ramakrishnan, 2014).

In line with the well-established role of GAP-43 in synaptic plasticity [49], these findings indicate that the activity of neuronal growth-associated genes is not limited to strengthen the intrinsic molecular machinery that sustains neuritic elongation, but is also efficient in making the surrounding milieu permissive for process outgrowth and structural remodeling.

On the contrary, a tilt towards hydrogen peroxide generates an intracellular milieu permissive of death execution.

Classic angiogenenic mediators, notably VEGF and PDGF, drive both angiogenic and fibrogenic responses, and may also foster a milieu permissive for the development of hepatocellular carcinoma [ 13].

It remains to be directly addressed whether inhibition of pat-4/ILK or other integrin-complex components in adult animals could similarly promote a cellular milieu permissive for protein aggregation or misfolding.