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Future studies will be aimed at unraveling which are the temporal-spatial characteristics of RWs and their "instructive" or "permissive" interaction with molecular factors [28], [29].
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Several small molecules, including the natural product gossypol and synthetic compounds such as ABT-737 and obatoclax, act as BH3 mimetics in vitro, demonstrating more permissive interactions with multiple antiapoptotic BCL-2 family members.
A role for stromal cells in carcinogenesis has been suggested from studies of embryological development where instructive and permissive interactions, along with genetic factors, are required for programming and maintaining epithelial structure and function.
Neuronal development in the adult means the realization of the genetic potential of the precursor cells in close guiding interaction with the local permissive microenvironment.
Prdm14, which binds predominantly to distal regulatory elements (Ma et al., 2011), might also be important for priming by inducing a permissive state in enhancers in preparation for interaction with the cognate promoters.
We envisage that the late endosomal milieu disrupts the gH/gL interaction, with low pH playing an important permissive role; gH then changes its conformation to allow hemi-fusion [28] and displace gB-NT; this then allows gB to switch to its pro-fusion form and complete the fusion reaction.
In this way, interaction with the external world modulates growth-regulatory mechanisms to create permissive conditions for local neuritic remodeling.
CAFs actively participate in reciprocal interaction with tumor cells and with other cell types in the microenvironment, contributing to a tumor-permissive niche and promoting tumor progression.
My interaction with you is not physical".
For direct interaction with the electorate.
(He had little interaction with Bill Clinton).
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