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Interestingly, caveolin-1 knockout mice suggest a permissive function of the protein: while its absence leads to disappearance of caveolae in many organs, the mice are viable and fertile.
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Our models in which mutant septins act dominantly to interfere with septin function do not account for a "quality control" mechanism identified by others in which a wild-type septin "outcompetes" various nucleotide-binding-pocket mutant alleles for incorporation into septin rings at temperatures permissive for function of the mutants (Cid et al. 1998; Nagaraj et al. 2008).
Therefore, the ability of these vectors to interact with CAR is likely a function of the steric hindrance provided by these loops, reducing the ability of the fiber-knob domain to engage CAR in a permissive conformation.
Function of the enhancer.
d) While it is true that cerebellar output could be permissive for the function of a forward model rather than generating/providing that model per se, the hypothesis that it actually generates it has been influential in the field.
L. kluyveri appears to have the most permissive mechanism: 80% of the 148 KlARSs function in L. kluyveri (28% of which display weak ARS function) compared with only 17% KlARSs that function in S. cerevisiae, in addition, 95% of ScARSs function in L. kluyveri compared with only 42% of LkARSs that function in S. cerevisiae.
Kregenow and colleagues examined mortality as a function of permissive hypercapnia in patients enrolled in the ARDS Network VT study [ 4, 8].
The potential for hypercapnia to attenuate to the deleterious effects of high stretch mechanical ventilation in the clinical context has recently received strong support in a preliminary report from Kregenow and coworkers [ 82], in which those investigators examined mortality as a function of permissive hypercapnia in patients enrolled in the ARDSnet tidal volume study [ 2].
On balance, we think the permissive nature of the ordinance furthers, rather than constricts, free speech.
In some cases, the more permissive stance of the United States may well be justified.
To some extent, the permissive consensus of the European nations might provide legitimacy for the European integration.
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