While it remains formally possible that basal EGF receptor activity has a permissive effect on some LPA-induced signaling events, we conclude that LPA and EGF signal independently to regulate broadly overlapping sets of genes in MEFs.
However, genetic rearrangements have been documented in hTERT-immortalized epithelial cells or fibroblasts, especially after prolonged periods of culture, suggesting that telomerase expression may be permissive for events that promote cellular transformation [ 31- 36].
As a key early step in cardiac progenitor development has been postulated to involve changes in migratory behaviour (Christiaen et al., 2008; Tam et al., 1997), Aplnr signals may be instructive or permissive for this event.
In addition, these findings nurtured the alternative hypothesis of tumorigenesis, the stochastic model, claiming that every cancer cell has the ability to self-renew and to recapitulate the disease phenotype given that it enters a permissive environment, an event which has a very low probability.
Though the incubation clock begins only when the mother hawk settles down on the eggs, which might take a few days after laying, by even the most permissive interpretation of events, Tuesday was Day 36.
Although CNVs can arise by multiple mechanisms, a subset is driven by local genomic architecture permissive to recombination events that can lead to both deletions and duplications.
In addition to an inhibitory effect on non-coding transcription, spaced chromatin may be less permissive to re-initiation events [ 73].
The fact that we were able to elicit AMPAR redistribution with passive drug administration or passive light-activation indicates the permissive nature of these events for addiction.
This group of miRNAs may indicate the occurrence of field effects in GC because differentiated expression of these regulatory molecules can provide a permissive environment for subsequent events in gastric carcinogenesis.
