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This difference suggests that cellular interactions underlying the outgrowth of sufficient pioneer axons for afferent guidance can tolerate short, but not long, delays of settlement of replacement GPT neurons, which constitute the permissive benefit actually obtained from the plasticity of precursors in the ablated VZ.
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Recently, clinical studies have reported a potential benefit of permissive hypercapnia following cardiac arrest on survival and neurological outcome.
The matrix highlights the problems of incomplete prevention, unsafe nicotine sources, and poor treatment options, and demonstrates why permissive nicotine regulation could benefit public health: when prevention fails, results are bad.
If the risks of inhaled nicotine are this low and if at least one smoker can switch to addictive inhaled nicotine for every 50 ex-smokers and non-smokers who start using nicotine, then public health will benefit from permissive nicotine regulation.
If the transport time exceeds 1 hour, the detrimental effects of permissive hypotension may outweigh the benefits, and there may be a role for novel hybrid resuscitation [ 57].
Conversely, the same origin policy currently in use on the Web may be too permissive in some cases; it could benefit from a fine-grained access control mechanism if one was developed to support cookie sharing across domain boundaries.
These benefits underpin the rationale for permissive hypercapnia.
There is some evidence and recommendations to support both initial full energy enteral feeding ("full feeding") and low energy permissive underfeeding ("trophic feeding") with different risks and benefits described.
Use of a low transfusion threshold has been shown to be of benefit [ 1], as has a more permissive approach [ 2].
significant, HRQoL health-related quality of life, LOS length of stay, MV mechanical ventilation, PN parenteral nutrition; RCT randomized controlled trial Whereas the trials not reaching a protein delivery of > 1.0 g/kg/d consistently show no benefit of additional nutrition support versus trophic or permissive underfeeding in the ICU.
However, these kinds of studies benefit from a more conservative threshold than from a permissive approach.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com