Hence, the half site specific adaptations inferred for the E153R substitutions (i.e., global topological alterations and possible modifications on the 5'-NN first basis step) are, in principle, permissive for the adaptation individually inferred due the simultaneous T147F and K160R substitutions (i.e., a GT- TT dinucleotide step substitution at the center of the half site).
Since, as mentioned above, BlaP and TEM-1 share a high sequence identity and a similar three-dimensional structure, the permissive sites described for TEM-1 served as a basis to engineer hybrid BlaP proteins with the insertion of heterologous polypeptides) [ 11].
Indeed, the empirical evidence available from jurisdictions in which a permissive regime exists (as described in Chapter Four) provides no basis for believing that individuals seek assistance for ill-considered or frivolous reasons.
An innovative approach to defining "non-permissive", i.e. clinically poorly tolerated HLA-DPB1 mismatches on the basis of alloreactive T cell epitope (TCE) groups, was recently shown to identify subgroups of patients with significant risks of aGvHD and transplant-related mortality.
This simple genetic basis can also contribute to understanding the genetic architectures that are more permissive of sympatric speciation in general.
To explore the epigenetic basis of sepsis-induced transcriptional dysregulation of angiogenic genes, we compared several important permissive and repressive histone modifications with Pol II levels along these genes.
Previous studies (5, 6) provide strong evidence that the adult retina is a permissive environment for rod photoreceptor integration and development of new functional rod photoreceptors, establishing the basis for future photoreceptor cell replacement therapy for a number of retinal diseases.
Our identification of a spontaneously-immortalized (but not transformed) chicken embryo fibroblast cell line (DF-1) that is fully permissive for MVA growth and that can be engineered to stably express MVA genes provides the basis for a genetic system for MVA.
On this basis, it is clear that a variety of different features contribute to the formation of a quiescent or permissive microenvironment for hemopoietic stem cell differentiation and maturation within the bone marrow space, necessitating a more complex in vitro model.
Texas remains relatively permissive.
