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Therefore, the present results suggest that the intestinal permeation factor should be taken into account when designing SD formulations for the oral delivery of BCS class IV drugs including docetaxel, and that P85 could serve as a potential formulation excipient for enhancing the intestinal permeation of docetaxel.
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The obtained results in terms of permeated fluxes and permeation reduction factors (PRF) are herein presented and discussed.
The major objective of this work is the evaluation of the Permeation Reduction Factor (PRF) of natural oxides on Eurofer steel adding a known content of water and hydrogen to argon, used in substitution of helium.
Our results reveal that the coating forms a columnar structure, with evidence of epitaxy at the substrate coating interface, and that this coating can produce a permeation reduction factor for hydrogen of up to 20,000.
All experiments show that Incoloy 800 readily oxidizes and that permeation reduction factors (PRF) of at least 100 are easily obtained for typical blanket conditions.
The influence of the operation parameters, such as feed composition, temperature and permeate pressure was experimentally investigated in terms of permeation flux, separation factor, permeance and membrane selectivity.
The magnetophoretic drug permeation "flux enhancement factor" was found to increase with the applied magnetic field strength.
The effect of operating variables such as feed composition, feed temperature and feed flow rate on permeation fluxes, separation factor and pervaporative separation index were studied in order to optimize the operating variables.
Average permeation flux (j), separation factor and activation energy of permeation (EP) were calculated.
As a result, the hybrid membrane shows high separation factor and permeation flux of 1293 and 2397 g/m2 h, respectively.
The hollow structure of HZIF-8 nanospheres ensures the rapid diffusion of water molecules, thus elevating the permeation flux and separation factor simultaneously.
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