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Exact(32)
Permeability Surface area product.
where PS is the permeability surface area product of water at the BBB.
Within the accessed dynamic flow range (0.2 to 1.9 mL/min/mL), the data are adequately described by the Renkin-Crone model yielding a permeability surface area product of (1.53±0.46) mL/min/mL.
In order to study the permeability surface area product (PS), [51Cr]-EDTA was injected as a bolus dose (370 bq) followed by continuous infusion 0.33 ml/h (3.7 MBq/ml).
They found that maximum blood brain barrier permeability surface area product (PS) and percentage of injected dose per gram of brain were dependent on the OX26 densities on the surface of polymersomes.
Permeability surface area for glucose (PSglu) was calculated as described previously [ 7].
Similar(28)
Two gold-standard experimental measures of BBB permeability are logBB (the concentration of drug in the brain divided by concentration in the blood) and logPS (permeability surface-area product).
Quantitative parameters relating to tissue blood flow rate, permeability surface-area product and EES volume (all of which influence the rate and magnitude of enhancement seen) are obtained from modelling of contrast agent kinetics (Tofts and Kermode, 1991; Tofts, 1997).
In this model, b reflects the basal permeability-surface area (PS) product and a accounts for MBF-dependent PS changes.
Adult male Sprague-Dawley rats (n = 35) (Taconic Copenhagen, Denmark) were used to investigate the brain water content and the permeability-surface area product (PS) for [51Cr]-EDTA.
The experimental data represented in vivo log PS (permeability-surface area product) from in situ perfusion, brain uptake index, and intravenous administration studies.
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