Sentence examples for permeability glycoprotein from inspiring English sources
permeability glycoprotein.
Additionally, the effect of drug efflux transporter permeability glycoprotein (P-gp) on the tumor uptake of tracers was explored by therapeutic blocking with tariquidar.
Cryosections of frozen xenografts (A549, H1975, and HCC827) were immunostained for the assessment of EGFR and permeability glycoprotein (P-gp) expression.
In this direction, we designed a new amperometric sensor (a medical device prototype) to detect drug resistant cancer cells by sensing "Permeability glycoprotein (P-gp)".
Furthermore, TPGS could improve drug permeability through cell membranes by inhibiting P-glycoprotein (permeability glycoprotein, abbreviated as P-gp), thus enhancing absorption of drugs and reducing P-gp mediated multi-drug resistance in tumor cells [10–13].
In addition, LY2428703 was not a substrate for efflux transporters at the blood brain barrier, as assessed in genetic knockout mice for ABCB1 (permeability glycoprotein (P-gp)) and ABCG2 (breast cancer resistance protein (BCRP)) [10].
In this Letter, we describe our efforts to design HEA BACE-1 inhibitors that are highly permeable coupled with negligible levels of permeability-glycoprotein activity.
In doxorubicin- and mitoxantrone- resistant MCF-7 breast cancer cells, both drugs led to decreased drug accumulation and enhanced drug efflux but only doxorubicin resistant cells had an increase in permeability factor glycoprotein-p170 (Pgp) expression [ 65].
In parallel, medical researchers were tracking down the gene encoding permeability-glycoprotein/P-glycoprotein (P-gp), a large glycosylated membrane protein associated with multi-drug resistance in mammalian cells [ 4].
TPGS enhances the drug permeability by P-glycoprotein efflux inhibition.
Nanoscale hydrogels were designed to overcome physicochemical and biological barriers associated with oral delivery of hydrophobic therapeutics such as low solubility and poor permeability due to P-glycoprotein related drug efflux.
