Obviously, don't do any pranking that involves something permanently damaging or harmful, including permanent alterations to the appearance, illegal activity, dangerous activity or reputation damage such as posting photos/videos on the Internet.
Non-genetic variation enables cells to adapt to short-lived environmental changes without permanently accumulating potentially harmful mutations [31], [78].
Most experts warn that placing children on restrictive, low-calorie diets without a compelling medical reason and a doctor's supervision is particularly harmful because it can permanently stunt growth.
A permanently occurring problem in bone tissue engineering is that unstirred and consequently harmful layers of fluid within growing tissue can arise.
Evil is both harmful and inexplicable, but not just that; what defines an evil act is that it is permanently disorienting for all those touched by it.
If the person is just really annoying and you don't have the heart to say it, just say that you're not enjoying the friendship, that the friendship is harmful for you, or that you'd just like to spend some time apart from the person — permanently.
"The fact that at least 21 students were permanently excluded from their studies for simply possessing a drug, and one in four students caught with drugs for their own personal use were reported to the police, is archaic and harmful.
