Sentence examples for permanently activated from inspiring English sources
Cancer originates when the "accelerator" genes are permanently activated or when the "brake" genes are permanently damaged.
The prevalent model proposes that BvgS is in a permanently activated state in the absence of ligand, unlike classical sensors of TCS.
Regarding its interaction with degradation, experiments by Kitamura et al [97] on FOXO1 in betaTC3 cells (pancreatic cells, in which Akt is permanently activated by endogenous insulin) show that acetylation exerts a strong protective effect against degradation.
Proto-oncogenes, when mutated, unleash their oncogenic potential primarily by remaining in a permanently activated state.
These results suggest a central role of HSP90 in permanently activated Jak-STAT signaling in cHL cells.
In RA, however, SFBs are permanently activated by cytokines, e.g., TNF- α and IL-1 β, which are potent pro-inflammatory cytokines especially produced by macrophages [ 16, 18].
A low-salt diet permanently activates a set of salt-retaining hormones that have, in test tube and animal experiments, been shown to have effects that might promote heart attacks and strokes by narrowing blood vessels and damaging their lining.
It seems this change permanently activates the protein so that more black than brown pigment is produced.
In particular, truncated p53 alleles that permanently activate the endogenous p53 protein display accelerated aging (Tyner et al., 2002; Maier et al., 2004) and reduced tissue function and regeneration, which suggests a defect in stem cells activity (Dumble et al., 2007; Gatza et al., 2008; Medrano et al., 2009).
Using the Ccsp-rtTA tet(O)Ccsp-rtTA tete tO Cremousetlinectovate green fluorescent permanentlyP) reporter expression in the context of activatee tracingreeneriment, it was reported that club cells (secretoglobin, fluorescentember 1 (Scgb1a1+)) give rise to club and goblet cells, whereas neuroendocrine cells remained unlabelled [11].
While many of the oncogene-induced DDR foci are resolved, some persist and thus permanently activate DNA damage checkpoint that consequently engages the senescence response.
