Sentence examples for permanent silence from inspiring English sources

Are you really as brain-dead as you sound?" As much as one might want an answer, doubting Thomas was stung into virtual permanent silence.

He would only be safe, they said, if he disappeared from his own life and maintained a permanent silence.

This line by President Uhuru Kenyatta was preceded by his prolonged; seemingly permanent silence over the social media postings of the deceased government critic Jacob Juma; postings that adversely mentioned both the president himself and his deputy as complicit.

Although it is generally believed that noncytolytic eradication of cccDNA from virally infected cells or permanent silence of its transcription is essential for a cure or durable control of HBV infection, promising approaches and molecular targets for therapeutic elimination and/or silence of cccDNA have not been identified.

Sceptics point out that Swedish justice (crime novels aside) is not generally known for scheming ferocity, or for the permanent silencing of America's foes.Clearly, anyone who protects WikiLeaks or Mr Assange (Ecuador has offered him unconditional asylum) faces American wrath.

Conversely, the methylation of CpG sequence can lead to the permanent silencing of genes.

This mark is involved in heterochromatin formation and in the permanent silencing of specific genes in transcriptionally active euchromatic regions when appropriate [16], [17].

Bivalent histone marks provide a switch mechanism shown to be involved in transcriptional regulation of developmental genes; loss of the H3K27me3 mark leads to transcriptional activation whereas loss of H3K4me3 results in permanent silencing [19].

All ASThiPS cell lines showed permanent silencing of the reprogramming transgenes, and displayed expression levels of the endogenous reprogramming genes that were comparable to hES cells (Figure 2A and data not shown; for a complete description of the primers used, see Table S2).

The mechanisms that destabilize the stable replication of the epigenetic information and lead to permanent silencing are not completely understood but may involve transcriptional interference and change in the timing of DNA replication as we previously reported at other sites [54], [55], [56].

Methylation of promoter CpG islands is known to inhibit transcriptional initiation and cause permanent silencing of downstream genes.