Sentence examples for perk is required from inspiring English sources

Together our results strongly support the notion that PERK is required to limit acini development and that positive or negative perturbations in PERK signaling can lead to either blockade or hyper-proliferative acinar morphogenesis, respectively.

To explore if PERK activation is required for SENP3 degradation during OGD, we co-expressed HA-PERK and Flag-SENP3 in HEK293 cells.

Secondly, in Drosophila S2 as well as in mammalian cells ire1 but not perk and atf6 is required for the replication of Brucella melitensis, a bacterium which grows in an ER-like compartment [18].

PERK eIF2α kinase is required for the proliferation of the insulin-secreting beta- cells as well as insulin synthesis and secretion.

Biochemical and genetic assays using OSCC cells and modified murine embryonic fibroblasts demonstrated that intact PERK-eIF2 ATF4-CHOP signaling is required for PERK-eIF2 ATF4-CHOPnd OSCC death following celastrol treatment.

A recent study revealed that the GCN2-PERK-eIF2α-ATF4 pathway is required for survival and proliferation of cancer cells in response to nutrient deprivation (Ye et al, 2010).

However, in MDA MB 157, A549 and EC109 cells, treatment with rapamycin resulted in increased pAkt, but pERK was unaffected, further suggesting that class I PI3K inhibition is required to enhance pERK phosphorylation in these cell lines.

These data suggest that the Perk arm of the UPR is required for upregulation of luciferase activity of Bim UTR-wt during conditions of ER stress.

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These findings suggest that PERK, an upstream component of endoplasmic reticulum and nutritional stress-response pathways, is required for BRCA induction.

Considering the prominent evolutionary-conserved cross talk between MAPK and Notch pathways, we examined whether MAPK/pERK signaling is required for the activation of the Delta/Notch pathway by the hESC-produced factors [ 3, 6].