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Release of PERK from GRP78 allows PERK activation through receptor autophosphorylation. Activated PERK can phosphorylate and inhibit eukaryotic translation initiation factor 2 α (eIF2 α), potentiating the eIF2 α-independent translation and nuclear translocation of activating transcription factor (ATF -4 to induce gene expression of chaperones and transcription factors such as CHOP.
However, when the PERK arm of the UPR is activated by thapsigargin, PERK from haplotype B homozygote cells is more active in phosphorylating eIF2α when compared to PERK from cells homozygous for haplotype A. The haplotype that confers high risk for PSP produces the more active form of PERK, suggesting that activation of the UPR is pathogenic in PSP and not a protective response.
One perk from being the base shrink: control of the clicker.
Starting last in the field of 189 riders and wearing No. 1 -- the sole carry-over perk from his third successive victory last year -- the 30-year-old Armstrong was his usual dominant self in a race against the clock.
The luxury condominiums at the Millennium Tower in San Francisco include every conceivable perk – from a wine cellar and screening room to the opportunity to attend "fireside chats with local and international thoughts leaders" – but for Frank Jernigan, one of the best features is the "engineering" button on the house phone.
I have stood in line at the downtown Holiday Inn, where reserved seats for the track are sold for the next day's racing, and I have flashed the season's pass that Albany reporters used to receive as a perk from the New York Racing Association.
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perks from a Jack Welch dream.
"He never received any perks from anyone".
Peggy Drexler says there are perks from crying at work.
The rich get a host of small perks from the state.
I see no difference between this practice and that of doctors' accepting perks from drug companies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com