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In the peritonitis model of gout, depletion of peritoneal mast cells attenuated the neutrophil inflammatory response [ 18].
The role of mast cells in the normal synovium remains to be defined, although the importance of mouse peritoneal mast cells for defense against bacterial peritonitis suggests that one important function of synovial mast cells might be to monitor the vulnerable acellular joint cavity for early evidence of infection.
The same group additionally reported rat peritoneal mast cell degranulation towards unopsonized C. albicans36.
Furthermore, we show a specific Ca2+-dependent binding of the DBC to the membranes of rat peritoneal mast cells (RPMC) and basophils.
The effect was temporary and decreased over a 6 h period, opposing the description of Trevisan et al.36 who showed that rat peritoneal mast cells permanently killed C. albicans.
As we previously demonstrated in rat peritoneal mast cells or adipocytes, chlorpromazine is amphiphilic and preferentially partitioned into the lipid bilayers of the plasma membrane.
The present study provides the first strong evidence in favour of the hypothesis that dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one inhibit compound 48/80-induced 48/80-inducedeaserotoninereleasel mast cells, acting thus as mast cell stabilizers.
Similar(4)
Influence of treatment with collagenase and dispase on peritoneal-mast-cell transcription.
Influence of treatment with collagenase and dispase on peritoneal-mast-cell hierarchical clustering.
Kolaczkowska, E. et al. Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation.
Ajuebor, M.N. et al. Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10.
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