Sentence examples for peripheral volume of distribution from inspiring English sources

With respect to the structural model, matuzumab was initially distributed to a restricetd central volume of distribution of 3.7 l and an even smaller peripheral volume of distribution of 1.8 l, which indicated that matuzumab was not (largely) distributed apart from serum volume.

Pharmacokinetic parameters of phenytoin, such as total clearance and central and peripheral volume of distribution were influenced by body weight.

Kainate treatment influenced the plasma pharmacokinetics of quinidine by decreasing the clearance (CL) and the peripheral volume of distribution (V2).

Moderate or severe HI (Child-Pugh Class B or C) decreased CLM and the peripheral volume of distribution of dapagliflozin (V3P) by 29 and 60%, respectively.

This covariate relationship resulted in a linear increase in the peripheral volume of distribution of 4.10% for each year of age increase.

Individual PK parameter estimates derived from the population were most variable for apparent peripheral volume of distribution (Vp/F) and intercompartmental clearance (Q) (Table 4).

A three-compartment PK model with equalized peripheral volumes of distribution best described the data.

Given that protein binding of midazolam and nifedipine are similar, changes in fu and central and peripheral volumes of distribution were applied as per the final midazolam model.

Central and peripheral volumes of distribution and ka were determined from published two-compartment analyses of nifedipine pharmacokinetics in healthy volunteers (Table 1 ).

Finally, relationships between GA and the central and peripheral volumes of distribution and between free and albumin levels were not statistically significant.

A three-compartment linear disposition model revealed that the population parameter estimates (between subject variability,%) were central volume (V1) 24.6 (55.5%) L/70 kg with peripheral volumes of distribution V2 23.1 (49.6%) L/70 kg and V3 30.6 (78.9%) L/70 kg.