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There are some peripheral terminal interfaces in the embedded devices.
Intrathecal sumatriptan inhibited both + aThe authors considered that this was a peripheral effect on the trigeminal nerve [34], see text bThe authors concluded: "The simplest reasonable conclusion is that sumatriptan inhibited trigeminal afferent by a direct neuronal mechanism at the peripheral terminal".[22].[22]
Using design-based stereological methods, the exchange surface areas of peripheral (terminal and intermediate) villi and their fetal capillaries and the arithmetic and harmonic mean thicknesses of the villous membrane (maternal surface of villous trophoblast to adluminal surface of vascular endothelium) were estimated.
To insure that changes in action potential latency during our experimental protocol were not the result of hopping between different initiation sites in the peripheral terminal, we determined the largest current range over which a fixed latency was observed and set the stimulus current in the middle of this range (Fig. S1).
In lieu of this, one widely used approach is to investigate the soma of isolated DRG neurons with the assumption that the soma plasma membrane mimics the peripheral terminal plasma membrane regarding the expression of the same ion channels within the same intracellular milieu.
By contrast, in silico perturbation failed to predict the cytokine concentration response of the peripheral terminal cytokine KC correctly.
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Opioids applied topically can produce analgesia by binding to opioid receptors on peripheral terminals of sensory neurons.
Naratriptan and kynurenate inhibited capsaicin-induced CGRP release from the medullary brainstem but not from peripheral terminals innervating the dura mater.
This would explain the suppression of thermal responses, as there is no reason to assume that the peripheral terminals of the neurons lost their heat sensitivity.
The anti-migraine drug naratriptan did not inhibit capsaicin-induced CGRP release from peripheral terminals but inhibited the release from brainstem slices.
The anti-migraine drug naratriptan did not significantly inhibit capsaicin-induced CGRP release from peripheral terminals but inhibited the release from brainstem slices suggesting a potential central effect of triptans, if they penetrate the blood brain barrier.
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