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These data will add to the accumulating body of evidence on the successful implementation of LED FM in peripheral settings in disease endemic countries [10], [11], [25], as well as providing a sufficiently powered sample size for comparison of operational performance of the methods in a cohort of HIV-positive TB suspects.
Therefore, the findings in this review may not be applicable to peripheral settings.
While we acknowledge the limited generalisability, our study provides support for the deployment of rapid diagnostic tests in peripheral settings where microscopy is not available.
In contrast, although policies on syphilis screening of pregnant women have been in place, lack of suitable diagnostic methods challenge the implementation of syphilis testing in peripheral settings.
This includes issues relating to staff training, essential supplies and supportive supervision of the frontline HWs especially those working in remote rural or peripheral settings.
Results from this trial will build evidence for the effectiveness of expanding the delivery of this established prophylactic intervention to peripheral settings.
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Antibody-detecting rapid diagnostic tests (RDTs) can be performed in peripheral health settings.
Use of a CRP rapid test in peripheral health settings could potentially be a simple and affordable measure to better identify patients in need of antibacterial treatment and part of a global strategy to combat the emergence of antibiotic resistance.
In both the CNS vascular and peripheral neurogenic settings, ectopic expression of Gpr124 or Reck could compensate for their respective loss-of-function but no functional epistatic relationship could be detected, that is, the absence of one protein could not be rescued by overexpression of the other.
Ongoing use of Xpert in high TB burden countries will contribute to the evidence base on the diagnostic accuracy and clinical impact of Xpert in routine programmatic and peripheral health care settings, including settings where the test is performed at the point of care.
The commonest manifestation of EPTB is in most settings peripheral lymphadenitis [ 19, 21, 22].
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