The muscle discomfort of bruxism is mainly a peripheral phenomenon, resulting from muscle hyperfunction leading to destruction of the myofibrils and release of algogenic substances including myoglobin into bloodstream.
Taken together our data show that TRPA1 channels play a key role in the behavioral responses associated with pain hypersensitivity induced by NTG at trigeminal level and suggest that SP/neurokinin A and CGRP release may contribute to the central and peripheral sensitization phenomenon.
However, it is unlikely that the MTP is a specific peripheral pain phenomenon.
Peripheral cutaneous embolic phenomena have also been reported as "red spots" or "rash," which often presents before cerebral ischemic events [2, 3].
Due to a large volume of distribution a difference in the drug concentration found in heart and peripheral bloods the phenomenon of drug redistribution was observed.
Intensive urbanization has led to the depletion of vegetation and its replacement by impervious surfaces, resulting in the accumulation of thermal energy, with urban areas becoming warmer than peripheral areas, a phenomenon known as the Urban Heat Island (UHI).
Previous research has shown that the diameter of a circulating fluidized bed (CFB) has a significant effect on the heat transfer rates to peripheral walls, a phenomenon important for the application of CFBs as combustors and boilers.
To validate this phenomenon, peripheral blood monocytes were isolated from the five mice of group H2 that developed AA-amyloid deposits triggered by sonicated peripheral blood monocytes and AgNO3 injections.
Late complications mainly include secondary malignancies, bleomycin-induced pulmonary fibrosis, Raynaud's phenomenon, peripheral neurotoxicity, infertility, and psychological disorders (Fizazi et al, 2002a).
Patients with anti-SSA and anti-SSB antibodies also have a higher prevalence of extraglandular manifestations of SS such as subcutaneous vasculitis, Raynaud's phenomenon, peripheral neuropathy, cytopenias, arthritis, renal involvement, and interstitial lung disease.
