Importantly, reassembled organoids developed the inherent architectures of the embryonic kidney, including the peripheral progenitor niche and internally differentiated nephrons that were interconnected by a ramified ureteric epithelium.
The establishment of the peripheral metastatic niche has been linked to pro-tumorigenic conversion of stroma resulting from granulin-producing bone marrow cells [ 62].
Therefore, pseudogenization of M. leprae's sigma factors [ 19] and stress response genes, resulting in limited response to environmental stress conditions [ 24], may have contributed at least in part to its adaptive evolution and to its extremely specialized niche within peripheral macrophages [ 24, 25] and Schwann cells of peripheral nerves in humans [ 26].
Our results suggest the T3 compartment represents a death niche for peripheral B cells, and includes cells from both newly formed and mature compartments undergoing apoptotic death.
We find that the in vivo labeling data are consistent with a model in which the death rate among T3 B cells is higher than in any other subpopulations, suggesting this pool represents the principal death niche for peripheral B cells.
The paper offers insights into how socio-technical low-carbon transitions can be influenced by peripheral, disruptive and unanticipated niche-innovations.
As with Apple's Pencil and the Surface Pen, it's hard to imagine the peripheral as anything but a niche device for the time being.
This cell population formed multipotent clonal colonies in vitro, thus supporting the role of the CB as a neurogenic niche in the peripheral nervous system (Pardal et al, 2007).
Furthermore, peripheral nerves may harbor a progenitor niche containing Schwann cell precursors.
Later in development a subpopulation of hemocytes closely associates with the larval peripheral nervous system, establishing a hematopoietic niche [ 41 ].
