Sentence examples for peripheral mode from inspiring English sources
It is possible that several active molecules in CEppt or their derivatives may cross the BBB, yet it is possible that CEppt possess a peripheral mode of therapy.
Recent pre-clinical data suggests despite a peripheral mode of action, Lesogaberan may have similar inhibitory effects to Baclofen on experimentally induced cough [ 68].
A similar maximum effect in terms of TLESR reduction was observed in dogs in preclinical studies using lesogaberan at concentrations at which it has a strictly peripheral mode of action [ 21].
Via analysis of the membrane-bound state of the N-terminal peptide of annexin A1, it has been found that the peptide adopts a peripheral mode of binding and is oriented parallel to the membrane surface.
Based on animal studies with other mGluR5 NAMs, 3-[ 2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and 2-methyl-6-phenylethynylpyridine (MPEP), the effects of ADX10059 on oesophageal acid exposure are expected to reflect inhibition of TLOSRs through a peripheral mode of action.
Although recent evidence has highlighted the importance of an appetite-independent, peripheral mode of action, it is still unclear whether selectively blocking the peripheral system could potentially solve the problem of the central side effects, which thus far has led to the demise of the cannabinoid antagonists as useful pharmaceuticals.
Its 26 scene modes include a Peripheral Defocus mode that lets you capture a photo with a sharp foreground and a blurred background (or vice versa).
Scene modes total 26, including the Peripheral Defocus mode, which lets users take a photo where the foreground is in focus and background is blurred – or vice versa.
28 Because of its high lipid solubility, fentanyl is distributed in all human tissues and, in contrast with morphine, crosses the blood-brain barrier easily and quickly, which explains its strong analgesic effect and lower intensity of the common adverse opioid effects associated with a central (nausea and vomiting) and peripheral (constipation) mode of action.
For instance, Panasonic's new Scene mode, Peripheral Defocus, lets users take a photo where the foreground is in focus and background is blurred – or vice versa.
