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Degradation of proteins such as desmin, filamin, dystrophin, and talin (all located at the periphery of the Z-line) may disrupt the lateral register and integrity of the myofibril themselves as well as the attachments of the peripheral layer of myofibril to the sarcolemma.
Within 24 h, a mixture of mouse embryonic fibroblasts (MEF) and cells, derived from the dorsal root ganglion (DRG) (sensory neurons and Schwann cells) grown in hanging drops, assembled to coherent spherical microtissues characterized by a MEF feeder core and a peripheral layer of DRG-derived cells.
Bugliarello and Sevilla [13] and Cokelet [14] have shown experimentally that for blood flowing through narrow blood vessels, there a peripheral layer of plasma and a core region of suspension of all the erythrocytes.
On autoradiography however, a focal uptake of 67Ga-P04087 in the valve area was present and histological slices demonstrated localization of peptide binding at the peripheral layer of vegetations.
Infiltration of the sample had been verified comparing the infrared spectra (ATR mode with germanium crystal) of the peripheral layer of the sample (in Figure 1 marked with number 1) which was embedded into synthetic resin and another sample which had been pressed in KBr pellet.
Originally, steroids are not uniformly distributed in the yolk of freshly laid eggs, and vary across yolk layers, with high oestradiol concentrations in the centre, high androstenedione and testosterone concentrations in the middle and high progesterone concentrations in the peripheral layer of the yolk sphere [55], [56], [58].
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With more porous samples, the embedding material penetrates into the open pores or cracks, especially in the peripheral layers of the sample.
Furthermore, leatherbacks are thought to possess counter-current heat exchangers in both the anterior and posterior flippers [9], have thick layers of adipose tissue surrounding cranial structures including the esophagus to prevent heat loss from the animal's head [10] and have peripheral layers of fat which include deposits of brown adipose tissue [11].
BODIPY-taxol accumulation in the peripheral layers of TS was also rapid, as evidenced by the similar degree of fluorescence intensity at 5 and 30-min incubation.
In well and moderately differentiated squamous cell carcinomas, K5 is preferentially localized in the peripheral layers of the tumor cell formations (Fig. 4c), corresponding to the K5 expression in the basal cell layer of normal stratified squamous epithelia.
Typically, the keratinizing centers of the cellular nests in CK-160 tumors showed significant staining for pimonidazole and HIF-1α, whereas a diametrical staining pattern was seen for CAIX with positive staining primarily in the peripheral layers of the nests.
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