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The peripheral gene expression studies reviewed in this section demonstrate the feasibility of peripherally extracted coding and noncoding RNA to provide insights into brain-based disorders.
There is a substantial literature relating brain function to genetic variation between individuals26 as well as work suggesting that gene expression in peripheral blood may be associated with psychiatric disorders27, but no work to date has directly examined relations between peripheral gene expression and brain function.
These are consistent with the "peripheral" gene regions described by Mudge et al. [21].
Several studies exploring peripheral gene expression using microarray technology were recently published.
These studies highlight the potential for the use of peripheral gene expression in investigations of the underlying pathophysiology of mood disorders and SZ.
De and colleagues [ 63] performed a large peripheral gene expression study encompassing actively medicated SZ subjects (N = 92), unmedicated SZ (N = 29), and 118 healthy controls.
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Through these hub genes, Rx3 may act indirectly to regulate more peripheral genes in the network [ 62].
For example, their inactivation is likely to cause a higher transcriptomic heterogeneity increase than that of more peripheral genes.
There was a small group of central genes (mostly belonging to SCC) that has a much larger number of peripheral genes in the network connected to them.
We prepose that different sets of peripheral genes in the above 16 regulons have appeared due to independent expansion of regulons in each lineage.
We tested core and peripheral genes separately, aligning the orthologous sequences using ClustalW 2.0.12 (Thompson et al. 1994) and counting nonidentical sites, excluding gaps.
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