Although based on the number of T-cell clones obtained upon in vitro culture we cannot evaluate the peripheral frequency of Tr1 cells of host and donor origin, our data suggest that in vivo FOXP3WT Tr1 cells, differently from nTregs, do not display preferential growth, as compared with their FOXP3null counterpart.
Although the role of Th17 cells has been investigated in several lung diseases, such as asthma [ 14], tuberculosis [ 15], lung cancer [ 16], and chronic obstructive pulmonary disease [ 17], there are few data about the peripheral frequency of Th17 cells in ARDS patients.
Peripheral blood frequencies of mononuclear cells did not significantly decrease during treatment with oxaliplatin/capecitabine.
A comparison of peripheral blood frequencies of CD25brightCD4+ T cells between patients and healthy subjects showed significantly lower levels in the rheumatic patients, indicating a selective recruitment of regulatory T cells in the inflamed joint.
In the peripheral blood, abnormal frequencies of pre-immune B cells, including transitional B cells, pre-naïve B cells, and naïve B cells, can be detected [ 11].
Overexpression of CXCL13 in inflamed glands with consequent local retention of CXCR5-bearing B cells [ 28, 30] might also lead to reduced frequencies of peripheral CD27+ memory B cells expressing lower levels of surface CXCR5 than peripheral B cells of healthy donors [ 26].
However, the frequencies of peripheral and hepatic Th17 cells are much higher in AIH patients compared to CHB patients.
At variance, Veltkamp described reduced frequencies of peripheral blood Tregs in active IBD [ 25].
Frequencies of peripheral blood monocyte subpopulations were analyzed by flow cytometry in 86 healthy controls and 75 RA patients.
In particular, lower frequencies of peripheral oedema and aggravated hypertension were recorded for licofelone compared with naproxen.
