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To date, no investigation as to the exact thymic and peripheral expression of a naturally occurring positive selecting self-peptide MHCII (self-pMHCII) complex has taken place.
In prion disease, the peripheral expression of PrPC is necessary for the transfer of infectivity to the central nervous system.
The peripheral expression of PrPC is essential for transfer of infectivity to the central nervous system [6] and the efficiency of neuroinvasion is influenced by the level of expression of PrPC [7].
We also observed strong peripheral expression of TH and the two Ddc orthologues (Fig. 5a; Additional file 7).
We hypothesized that the peripheral expression of CCR3 would reflect the local CCR3 expression in the choroid.
We sought to determine the role of peripheral expression of HDAC4 by using a cKO approach in mice.
Similar(39)
Basiliximab induction resulted in a transient increase in CD4+FoxP3+ Tregs, accompanied by the highest peripheral expression levels of markers associated with operational tolerance (FOXP3 and TCAIM).
To test whether phenotypic host preference may be associated with the peripheral expression profiles of chemosensory genes such as chemoreceptors and Obps, we have isolated and sequenced mRNA from the antennae of An. gambiae and An.
One possibility is that these changes in opioids may be explained by the influence of sex hormones on the peripheral expression and potency of endogenous opioid peptides and their receptors.
CCR7 expression was either extremely low or undetectable on pDCs and mDCs (fig 1A,B) consistent with prior reports of low peripheral expression levels in unstimulated pDCs.
Further in-vivo investigations with respect to peripheral MCHR1 expression of healthy, obese and diabetic rats need to be performed to further proof the applicability of the MCHR1 concept.
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