Percent body fat (%BF) measures total body fatness, which is composed of central and peripheral fat, estimated by waist circumference (WC) and skinfold thickness, respectively.
Although benign, they have the potential to undergo malignant transformation into peripheral chondrosarcomas, estimated to occur in 1%–5% of patients.
No differences were observed among arms with respect to insulin sensitivity of the peripheral tissues, estimated by HOMA2-%S (Supplementary Table 2).
The distribution rate constant describing water exchanges between the central and peripheral compartment estimated with the 2-CM (d = 18 ± 6 min) showed that water left the central compartment with a very short half-life (td½ = 12.5 ± 4.3 min, i.e., only slightly longer than the ta½ estimated with the 2-CM).
Secondary objectives were to: identify a dose response for various biomarkers in the peripheral blood; estimate the minimum biologically effective dose (BED); determine the pharmacokinetics of IL-21; determine if anti-IL-21 antibodies were induced during therapy; and measure effects on tumor size.
Central motor conduction time (CMCT) was calculated by subtracting the conduction time in peripheral nerves, estimated by conventional F-wave techniques, from MEP latency obtained during moderate active muscle contraction (10%20%% of maximum background force), at a stimulus intensity set at 130% of the rMT [ 29].
Central motor conduction time (CMCT) was calculated by subtracting the conduction time in peripheral nerves, estimated by conventional F-wave techniques, from MEP latency obtained during moderate active muscle contraction (10 20% of maximum background force), at a stimulus intensity set at 130% of the rMT [ 37].
Our study showed that MIP in critically ill patients significantly correlated with the MRC muscle strength score which estimates peripheral muscle strength.
It is noteworthy that the early glucose response during a GTT can be considered an index of hepatic IR, while the drop in glucose levels from peak to nadir estimates peripheral IR predominantly of skeletal muscle with a smaller contribution from adipose tissue [ 30].
As these analyses were done on a sample of unseparated lymphocytes from peripheral blood, the estimates were confounded by the age-associated decrease in frequencies of naïve T cells in blood samples, which emphasizes the importance of studying purified cell subpopulations.
