Sentence examples for peripheral endings from inspiring English sources

SP/NKA and CGRP release from peripheral endings of nociceptors promoted by TRPV1 or TRPA1 activation produces a series of responses collectively described as neurogenic inflammation [48].

First, CGRP is present not only in the peripheral endings of trigeminal nerves close to dural vessels but also in the trigeminal nucleus itself [28 30].

During the last 20 years cloning of their receptors and identification of selective antagonists [3 6] have provided powerful tools to unravel their functions when liberated from central and peripheral endings of pseudounipolar somatosensory neurons.

Importantly, chemosensitive afferents besides conveying nociceptive information to the central nervous system release vasoactive peptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP) from their peripheral endings producing a sterile neurogenic inflammation [4 8].

Since formalin is able to activate TRPA1 channels [31], this reduction is probably linked to the antagonist action of ADM_12 on the TRPA1 channels localized at the peripheral endings of the primary sensory neurons or on non-neuronal cells.

It is widely recognized that a certain subset of primary afferents synthesize, store and release neuropeptides (such as tachykin­ nins and calcitonin gene-related peptide) from their central and peripheral endings, the latter being widely distributed in the alimentary canal and related organs (liver, pancreas).

The toxin acts on peripheral nerve endings, preventing the release of the neurotransmitter acetylcholine, which conveys nerve signals to muscles.

The stimulation of additional peripheral nerve endings has an inhibitory effect on the nerve fibres generating the pain.

(Nociceptors are peripheral nerve endings specialized to respond, normally, only to potentially damaging stimuli, i.e., to nociceptive stimuli).

During the pain phase in migraine the trigeminal complex is activated and neuropeptides are released at the peripheral nerve endings [14].

These findings suggest that nicotinic receptors on peripheral nerve endings in the respiratory tract modulate smoking satisfaction and may be important in the maintenance of cigarette addiction.