Sentence examples for peripheral effects that from inspiring English sources

While aging has historically been thought to entail cell-autonomous, even stochastic changes, recent evidence suggests that modulation of this process can be hierarchal, wherein manipulations of nutrient-sensing neurons (e.g., in the hypothalamus) produce peripheral effects that may modulate the aging process itself.

Leptin is a circulating hormone/cytokine with central and peripheral effects that is released mainly by subcutaneous white adipose tissue.

This helps separate the therapeutic effect of MSF in the brain from the undesired peripheral cholinergic side effects that are commonly experienced with the currently available short-acting AChEIs which also may limit dosing to what can be tolerated by the patients.

On the basis of our findings it could be recommended that AETS exhibits peripheral analgesic effect that might be mediated by inhibiting, either the response or releases of noxious mediators that leads to sensitization and activation of peripheral nociceptors.

43 Their results suggest the SAA is limited to peripheral activity, not central anticholinergic effects that may impact cognition.

Here, we present a variation of rotational effects that highlights the dependence of peripheral illusions on contrast with the background (peripheral reversal illusion).

MSCs also exerted anti-inflammatory effects that might be important in maintaining peripheral tolerance [14, 15].

However, sibutramine exerts a peripheral sympathomimetic effect that induces a moderate increase in heart rate and attenuates the reduction in blood pressure attributable to weight loss or even slightly increases blood pressure.

Injection of leptin into the ventromedial hypothalamus increases glucose uptake and decreases hepatic glycogen without any alterations of plasma insulin or glucose levels suggesting that peripheral effects of leptin on glucose metabolism are mediated by the central nervous system [ 20].

As mentioned, we narrowed our search to proteins present in serum/urine because of the postulated presence of a circulating diabetogenic factor that exerts peripheral effects.

It is therefore very likely that the peripheral effects of resveratrol might compensate for the responses induced at the central level.