Sentence examples for peripheral effects on from inspiring English sources
Leptin also exerts peripheral effects on BAT since peripheral, but not central, administration of leptin in rats increases the insulin-stimulated utilization of glucose in BAT.
The COMT-inhibitor tolcapone has both central and peripheral effects on the dopaminergic metabolism in contrast to the COMT-inhibitor entacapone, which only acts peripherally.
This altered inflammatory profile can have peripheral effects on the liver [ 78], and during pregnancy, can result in enhanced placental and fetal inflammation [ 79].
In summary, we have elucidated the significance of the functions of dSir2 in the fatbody in mediating central and peripheral effects on metabolic homeostasis and insulin signaling.
A facilitation of CB1 signaling at this site may well explain the antinociceptive effects and may be contributed by peripheral effects on CB1 receptors of nociceptors (Agarwal et al, 2007).
It has peripheral effects on skeletal muscle, liver, pancreas, adipose tissue, and other cell types where it acts to decrease anabolic pathways (such as glucose, lipid, and protein synthesis) and increase catabolic pathways (glucose and lipid utilization).
Although no one is questioning the peripheral effects of OLZ on metabolism, it is unclear whether the peripheral effects are a result of a primary central mechanism.
To examine the peripheral effects of BAL on the neutrophil counts and cytokine levels in the circulation.
In particular, the strong peripheral effects of OLZ on decreasing RER (reducing glucose utilization) have not been examined after central administration.
A peripheral effect on trigeminal vascular nerves was indicated by the blocking effect of sumatriptan of neurogenically mediated plasma extravasation [8].
Intrathecal sumatriptan inhibited both + aThe authors considered that this was a peripheral effect on the trigeminal nerve [34], see text bThe authors concluded: "The simplest reasonable conclusion is that sumatriptan inhibited trigeminal afferent by a direct neuronal mechanism at the peripheral terminal".[22].[22]
