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While peripheral effects in adults often go away when lead exposure ceases, evidence suggests that most of lead's effects on a child's central nervous system are irreversible.
Five of eight articles stated this [57].anofi-sponsored researchers claim that hepatocytes contribute to rimonabant's peripheral effects in mice [73].
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Some central effects have been mentioned, but the peripheral effect in reducing sympathetic tone and a possible antiinflammatory action may also be involved [ 24– 26].
Considering the potential inflammatory properties, there seems to be a discrepancy between high concentrations of serum S100A8/A9 and the lack of its peripheral effect in patients with RA.
Taken together, these studies with amlodipine and nifedipine GITS suggest that BP reduction and the effects on the sympathetic nervous system reflect a dynamic equilibrium between central and peripheral effects, which, in turn, are dependent on peripheral (plasma) and central (central nervous system) concentrations of drug.
Therefore, one may speculate that the increased cerebrocortical effect of insulin detemir in presence of comparable peripheral effects might be involved in the beneficial effects of insulin detemir on body weight development during insulin treatment.
However, the intensity of these peripheral effects is typically lower in the sham condition than in TMS and only TMS elicits muscle twitches and stimulates facial muscles.
Peripheral effects of endurance training in young and old subjects.
In the current trial, we evaluated the peripheral effects of an HFS diet in adult female rats that had experienced an MS paradigm.
The COMT-inhibitor tolcapone has both central and peripheral effects on the dopaminergic metabolism in contrast to the COMT-inhibitor entacapone, which only acts peripherally.
Sanofi-sponsored research has highlighted adipose tissue in rimonabant's "peripheral effects" (e.g., [67]).
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