Exact(35)
It was found that the extract at a dose of 150 mg/kg was highly effective producing 80.663% inhibition in phase II, suggesting a strong peripheral effect (Table 4).
It is however unlikely that the action of OnaA is limited to a peripheral effect.
No significant effect of metoprolol on trigeminal pain processing was observed, suggesting a peripheral effect of metoprolol.
A peripheral effect on trigeminal vascular nerves was indicated by the blocking effect of sumatriptan of neurogenically mediated plasma extravasation [8].
The authors' conclusion was that it could be a peripheral effect of the drug because "sumatriptan is a selective 5-HT (1B/1D) receptor agonist that does not cross the blood brain barrier" [60].
Intrathecal sumatriptan inhibited both + aThe authors considered that this was a peripheral effect on the trigeminal nerve [34], see text bThe authors concluded: "The simplest reasonable conclusion is that sumatriptan inhibited trigeminal afferent by a direct neuronal mechanism at the peripheral terminal".[22].[22]
Similar(24)
Through both central and peripheral effects, doses lower than those used to relieve pain may be effective in opioid naïve patients.
The proposed remedies, some critics said, treat some peripheral effects of the crisis rather than its thorniest causes.
The peripheral effects are just as crisp and clear as the center of the field of view.
Noradrenergic pathways are involved in mediating the central and peripheral effects of physiological arousal.
To examine the peripheral effects of BAL on the neutrophil counts and cytokine levels in the circulation.
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