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With prostate brachytherapy, the entire prostate is treated to a minimum peripheral dose of 145 Gy.
Only 0.02% of a peripheral dose of morphine or the anti-depressant Fluoxetine enters the brain, yet this level is sufficient for clinical effects (Advokat and Gulati, 1991).
Summary: A single peripheral dose of a recombinant natural human IgM increases lifespan and delays neurological deficits in mouse models of human ALS.
We previously reported that a single peripheral dose of rHIgM12 preserved neurological function in a murine model of demyelination with axon loss.
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This paradigm may model infection arising from exposure to larger peripheral doses of infectivity, as the relatively long period of replication in the spleen that would normally be seen in peripheral administration is bypassed in this instance, suggestive of direct neuroinvasion [11].
Central activation of CB1 mediates the rapid effect of glucocorticoid negative feedback and this might explain the necessity for high peripheral doses of the CB1 antagonist rimonabant to increase cortisol levels [ 120, 121].
Chronically decerebrate rats, which lack direct neural connections between the hindbrain and forebrain, significantly reduce food intake in a manner comparable to intact rats when treated with peripheral doses of mCPP or d-fenfluramine, a drug which increases serotonin release and inhibits serotonin reuptake [8,12].
Peripheral dose falloff was compared by using the metrics volume of normal brain receiving more than 12-Gy dose (V12) and CI at the level of the 50% of the prescription dose (CI 50%).
Methodologies have to be developed for determination, description measurement and calculation of doses outside the planning target volume (PTV) for radiation therapy, i.e. the peripheral dose.
Accurate measurement and knowledge of dose delivered under eye shield during superficial X-ray radiotherapy is required for patient peripheral dose assessment.
The increasing interest of the medical community to radioinduced second malignancies due to photoneutrons in patients undergoing high-energy radiotherapy, has stimulated in recent years the study of peripheral doses, including the development of some dedicated active detectors.
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