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Electron microscopy of the muscle revealed abnormalities in nuclear architecture, i.e. blebbing, thick lamina and peripheral distribution of heterochromatin.
WB scintigraphy and static images of the hands of a woman suffering axial SpA are depicted in Fig. 2 and illustrate the 'normal peripheral distribution' of 99mTc-S-HYNIC CZP.
Evidence from BSE inoculation of primates indicates similar peripheral distribution of disease associated PrP following either oral or intravenous infection.
The peripheral distribution of PrPSc has been well characterized in rodent models of prion diseases [32], [33].
We showed that NF-L loss reduced axonal levels of both Myo Va and organelles and increased peripheral distribution of ER toward the actin-rich subaxolemmal region.
The effect on the peripheral distribution of ER in Myo Va mutant axons was less prominent though similar compared to that in NF-L null axons.
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The peripheral distributions of GGO and centrilobular emphysema (CLE) were significantly less prevalent in non-survivors (p=0.0032 and 0.015, respectively).
Disjunct peripheral distributions of diploid species with related polyploid cytotypes in the centre of the Alps have been observed, for example, in the R. auricomus complex (Paun et al., 2006; Hörandl, 2009 a) and in sexual Biscutella laevigata (Parisod and Besnard, 2007).
Inter-individual variability could be estimated for all fixed effects except for the first pass effect of artesunate, artesunate elimination clearance, central distribution volume of artesunate and peripheral distribution volume of dihydroartemisinin (Table 2).
The structural PK model of cyclosporine indicated an apparent clearance (CL/ F) of 15.9 l/h, with the bioavailability term fixed to 0.5, an apparent central distribution volume (Vc/ F) of 59.6 l, and an apparent peripheral distribution volume of 99.7 l.
The structural PK model of everolimus indicated an apparent clearance (CL/ F) of 16.7 l/h, with the bioavailability term fixed to 1, an apparent central distribution volume (Vc/ F) of 144 l, and an apparent peripheral distribution volume of 348 l.
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