Sentence examples for peripheral differentiation from inspiring English sources

Furthermore, similarly to gut intraepithelial γδT cells, eosinophils are able to undergo peripheral differentiation, for instance in allergic lungs [49].

Together with IL-2, it is important for the peripheral differentiation of suppressive, induced Tregs that also express the Treg specific transcription factor FOXP3 [10].

B cells are susceptible to mitochondria- and receptor-initiated death at various stages of peripheral differentiation and during immune responses, which plays an important role in maintaining homeostatic control of B lymphocytes [38], [39].

In addition, the author could circle back to this after the more novel discussions of peripheral differentiation.

The typical lesion of myositis ossificans shows a zoning effect with peripheral differentiation into well formed bone and a lack of cytologic atypia [ 3].

Alternatively, as Helios expression was more recently shown to be induced upon T cell activation (Akimova et al., 2011) preceding Foxp3 induction on peripherally induced Tregs (Gottschalk et al., 2012), it may be that our expanded Treg population reflects peripheral differentiation of naïve OT-II T cells into OT-II Tregs.

The detailed understanding of molecules and pathways involved in peripheral Treg differentiation might provide new therapeutic targets for the treatment of disorders caused by dysregulation of Tregs, such as autoimmune diseases, chronic infection and graft rejection.

Changes in CNg V or other ganglia and nerves might reflect altered hindbrain neural crest specification or altered peripheral target differentiation, including epibranchial placodal contributions to the developing ganglia.

These clusters were found to be responsible for the accumulation of CD4+CD25+Foxp3+ Treg (Helios−, CTLA4, and IL-10high) in the colonic lamina propria [ 73] and suggested that Clostridia are potent inducers of peripheral Treg differentiation and proliferation, presumably in the gut.

During the postoperative period, the in situ regeneration was boosted by administering bioactive molecules to promote peripheral mobilization and differentiation of stem/progenitor cells and ultimately the regenerative process.

Fld mice exhibit life-long deficiency in adipocyte differentiation, peripheral neuropathy, circulating hyperlipidemia, and neonatal hepatic steatosis [19] [21].