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But they say it is really the notion of "presence," of being in constant peripheral contact with the cast of characters that defines one's life, that makes IM such a powerful, intimate -- and potentially burdensome -- form of communication.
It's about the moment when an architect realizes that his beloved newborn design is not going to survive: "You double your efforts — wax more eloquent, convince every skeptic, invest in the most peripheral contact, but you have seen the cold, cloudy eyes of waning commitment.
British officials have attributed their failure to tell the United States what they knew about Mr. Abdulmutallab to the suspect's own seemingly peripheral contact with Islamic extremists, saying he was not considered a terror threat himself.
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While the peripheral contacts and triple helical scaffold exhibit substantial burst phases, the slowest protection to appear is J8/7 in the catalytic core, which displays a minimal burst amplitude and whose formation is coincident with the recovery of catalytic activity.
In contrast, p85β deletion selectively reduced centrally localized cell adhesions without disturbing peripheral contacts and adhesion plaques that were enlarged in these cells (Fig. 3A,B); this indicates that p85β is needed for development of peripheral into central cell adhesions.
Similarly, ChIP shows that ∼500 fly genes contact lamin B – presumably at the periphery – and these genes are clustered on the genetic map, quiescent and mid-to-late replicating; when coordinately activated during development, peripheral contacts are lost [ 18].
The phenotypes induced by p85β expression in fibroblasts and BLM cells suggest that p85β induces maturation of peripheral contacts to central adhesions, as well as the development of F-actin-containing cell adhesions.
The marginals are either restricted to the peripherals or their borders coincide with the costo-peripheral contacts or, as in the case of marginals 5 and 7, they slightly lap onto the costals.
FISH signals were scored as peripheral (in contact with the nuclear lamina) or central (no contact with the nuclear lamina) using ImageJ software.
To identify factors from skin that induce CGRP, we developed a bioassay in which embryonic DRG neurons isolated before peripheral target contact in vivo are challenged in vitro with specific factors.
Peripherals 3, 4, and the anterior third of peripheral 5 contact the plastron via well-developed pegs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com