Exact(18)
The peripheral blast cell count correlated strongly with WBC (correlation coefficient: 0.99).
However, the data from the phase III study did not analyze peripheral blast count as an independent variable.
Mann-Whitney rank sum test was used for the differences in the median variable in hemoglobin level, WBC/platelet count, and peripheral blast percentage.
In this study, we also considered a pharmacodynamic response if a sustained reduction in peripheral blast cell counts was observed (longer than four weeks).
Two romiplostim-treated patients who had increases in peripheral blast cell counts initiated treatment for AML without undergoing bone marrow biopsies 4 weeks after discontinuing romiplostim.
We classified prednisolone poor responders (PPR) as patients with a peripheral blast count of ≥ 1 × 10/L on day 8 following induction treatment with prednisolone and a single intrathecal dose of methotrexate, while a prednisolone good responder (PGR) demonstrated a day 8 peripheral blast count of < 1 × 10/L (Table 1).
Similar(41)
When G-CSF was discontinued the peripheral blasts cleared and the patient achieved a complete remission.
GCSF was stopped in 1 patient due to persisting peripheral blasts.
The International Working Group score, based on age, constitutional symptoms, anemia, leukocytosis and circulating peripheral blasts, was highly predictive for survival after HCT.
The number of peripheral blasts of prednisone good responder (PGR) was <1000/ul, whereas the value of prednisone poor responder (PPR) was ≥1000/ul.
Group 1 (adolescents and young adults (AYAs)) presented with more aggressive disease features (larger spleen size, more frequent symptoms of organomegaly, higher white blood count, higher percentage of peripheral blasts and lower hemoglobin levels) than the other age groups.
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