Sentence examples for peripheral binding from inspiring English sources
Molecular modelling studies suggest that these compounds might bind at the peripheral binding site of AChE, which opens the possibility to design inhibitors able to bind at both, the catalytic and peripheral binding sites of the enzyme.
It is quite possible, that KA may also bind to this site or has a different peripheral binding site yet to be elucidated.
In addition to the peripheral binding site of KA (PDB 3NQ1), we have recently determined the structures of TyrBm with L-tyrosine, L-dopa and the substrate analog p-tyrosol35, all found within the active site.
The results demonstrate the presence of a peripheral binding site for an imidazolium group at the rim of the BoNTA active-site cleft.
The ability of this compound to interact with the AChE peripheral binding site was confirmed by kinetic studies and by molecular modeling investigation.
These new hybrids combined a tacrine, 6-chlorotacrine or acridine unit as catalytic binding site and indanone (the heterocycle present in donepezil) or phthalimide moiety as peripheral binding site of the enzyme, connected through a different linker tether length.
Therefore, it is possible that the MLV Env is opened up for fusion activation by the relocation of the RBDs in a two-step process: first, one site reacts with the peripheral-binding site in the RBD and then another one with the central site.
In a previous study we have already experimentally demonstrated that a peripheral KA binding site exists in TyrBm22.
However, safety liabilities associated with peripheral receptor binding and Fc effector function have been reported.
The new compounds 1 4 differed in their presumed AChE peripheral site binding moiety, which ranged from an azide group to functionalized heterocycles.
Besides the central gabaergic receptors described for benzodiazepines, peripheral type binding sites (PBR) were also identified for these molecules in endocrine steroidogenic tissues, immune organs and cells, such as macrophages and lymphocytes.
