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Peripheral accumulation of phosphorylated FAK and F-actin were detected only in FGF2- and VEGF165-stimulated (Figure 6B-C, upper panels), but not in serum-starved cells (Figure 6A).
Consistent with these studies, phalloidin stained DKO compared to control aortic EC demonstrated a dramatic loss of actin cytoskeletal organization, in particular the loss of intracellular stress fibers and marked peripheral accumulation of actin in both aortic and lung DKO EC compared to controls (Figure 5A and Figure S5A).
In our study, we showed for the first time that activation of the Trp catabolism in BALB/c mice caused a peripheral accumulation of Kyna which is a (N-methyl-D-aspartat) NMDA receptor antagonist and is known to contribute to the development of disorders such as depression and schizophrenia [34].
In cells overexpressing Arl8b, knockdown of SKIP prevented the peripheral accumulation of lysosomes.
Starch promoted peripheral accumulation of the later infused Ringer´s acetate solution and markedly prolonged the elimination half-life.
The described HES-induced peripheral accumulation of Ringer´s is likely to contribute to the tissue oedema frequently observed after lengthy surgery and intensive care.
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Long-term use can bring on a syndrome known as lipodystrophy (wasting of peripheral fat, accumulation of central fat, hyperlipidemia, and insulin resistance).
Long-term use can bring on a syndrome known as lipodystrophy (wasting of peripheral fat, accumulation of central fat, increased levels of fat in the blood, and insulin resistance).
Ranking the compounds by their peripheral nerve accumulation was cisplatin > carboplatin > oxaliplatin > R,R - DACH PtCl4≈ S,S - DACH PtCl4and did not correlate with neurotoxicity.
Adipose tissue is distributed mainly in the upper body (nape of neck, shoulders, epigastrium) in boys, whereas in girls peripheral fat accumulation in the lower body predominates.
It is difficult to tell whether that peripheral PrPd accumulation preceded neuroinvasion or resulted from centrifugal spread, but the lack of LRS involvement in those same deer rather supports the later possibility.
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