Your English writing platform
Discover LudwigExact(6)
With respect to CH several studies have explored potential relationships with clock gene variants due to the striking circadian and circannual periodicity of attacks.
However, the history, lacking the stereotypical periodicity of attacks, or neurological examination showing some abnormal findings, was worrisome for a secondary aetiology.
The periodicity of attacks and apparent sleep disturbances imply that CH is a chronobiological disorder, and that the hypothalamic biological clock (the suprachiasmatic nucleus, SCN) may be involved in CH pathophysiology [4].
Multiple choice items: about number of attacks; duration; quality of pain; intensity; aura symptoms; accompanying symptoms; periodicity of attacks; usual days of the week; usual time of head pain beginning; lateralization; location of start; triggering factors; relieving factors; worsening factors.
Because that part of the brain is responsible for, among other things, circadian rhythms, the daily cycle of our body that dictates when we sleep but also regulates body temperature and blood pressure, it could explain the periodicity of attacks and why they seem to occur particularly often around the solstices.
Irrespective of treatment options, an inevitable cessation of the steadfast periodicity of attacks will occur on average 4.5 years after the first attack [ 5].
Similar(54)
These include the presence of CAS, the clock-like periodicity of the attacks, and the presence of nocturnal attacks in CH (but not in TN) and the presence of trigger points (only in TN).
The circadian and circannual periodicity of the attacks is attributed to the activation of the HS.
Frequencies, duration, pattern (without periodicity) of the attacks were also more compatible with the diagnosis of PH.
It has been suggested that like the periodicity of inflammatory attacks in PFAPA, cytokine-producing cells in these patients may also display unique biorhythms [ 31].
Additional, discriminatory features that may aid in the differential diagnosis of PFAPA include the duration and remarkable clockwork periodicity of inflammatory attacks.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com