Given TRMT2A's strong prognostic association in HER2 expressing patients and its periodic expression during the cell cycle, it is interesting to speculate that TRMT2A over-expression may reflect tumor cells driven by an activated HER2 pathway towards aggressive growth.
Thus, the periodic expression of Sprouty4 potentially acts to periodically repress FGF signaling and thereby periodically modulate spatial information in the mouse PSM (Figure 6).
The proliferation-associated genes in other signatures have been selected on the basis of their periodic expression pattern during the cell cycle and include several genes that, although periodically expressed, are not involved in basic cell cycle processes [10], [37].
The orthologs of these genes with aligned MBP1 motifs were identified in S. bayanus and categorized into two groups: 1. those genes that preserved periodic expression during the cell cycle; and 2. those genes that no longer periodically expressed.
Periodic expression was only found for 21/392 genes, primarily expressed during the G1 and S phases.
We applied a previously published detector of periodic expression [ 19] that took into account the approximate period time of the cell cycle in the α-factor, cdc15 and cdc28 experiments reported by Spellman et al. [ 2].
Maternal factors and gap genes together regulate pair-rule genes (expressed in 7 stripes), which in turn regulate segment-polarity genes, whose periodic expression in 14 stripes constitutes the segmental pre-pattern.
The periodic expression of frustration with seemingly intractable or insoluble social problems led scholars to turn to questions of knowledge and its management and to pursue evidence as a more solid ground for policy research.
Thanks to its periodic expression, this putative orphan nuclear receptor could serve as a suitable cellular marker for studying changes of epidermal cell sensitivity to 20E during the cell cycle.
Other genes encoding proteins involved in photosynthesis also displayed periodic expression.
Probes derived from the intergenic regions displayed a considerably lower percentage of periodic expression (31%).
