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It has been assumed that mutations to the gene do not occur during the period of selection.
After detecting mutations that alter fitness and affect replication during this early period of selection, Carlson et al. made further comparisons within subsets of the cohort.
Thus, selection with DHODH inhibitors was superior in that it successfully selected transgenic Dd2 parasites, as well as yielded transgenic parasites after a shorter period of selection.
Genome-scale methods uniquely enable the calculation of clone fitness values by providing concentration data for all clones within a genomic library before and after a period of selection.
If sufficient variation accumulates during this neutral period, followed by another period of selection, the ultimately successful haplotype will likely be drawn from the standing variation.
A previous study did not observe [PSI+] induction upon Ssa1 overexpression [17], however, this is likely due to the shorter period of selection on adenine-deficient media normally employed.
Similar(42)
We conclude that, during viral growth under either extended periods of selection or conditions that led to disease, viruses resistant to guanidine were readily selected in mice while viruses resistant to V-073 were not.
Changes in coding sequences represented by these periods of selection, in both DNA-binding and non-DNA-binding regions of MADS transcriptions factors, seem to play important roles during phenotypic evolution of plants.
We show that there are two periods of selection against the mutated form, one early on possibly during satellite cell activation and the other during the rapid replication phase of myoblast culture.
Here Rhg1/Rfs2 was inferred to be a complex of three genes assembled and co-inherited over long periods of selection for resistance to a endemic pest, root parasitic nematodes.
It would appear that regenerating muscle cells are subjected to two periods of selection, with the first phase occurring very early on before myoblasts were assessed for mutation levels.
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