Exact(7)
This period of dosing encompassed the necrotic degenerative phase resulting from dystrophin deficiency.
Most antidepressants require a lag period of dosing ranging from 2 to 4 weeks for clinical effects of their administration to be apparent.
Chronic administration of MISO for an 8 h period gave no enhancement of melphalan damage, whether melphalan was given half-way through or at the end of the period of dosing.
Following the first fMRI session, all participants received a further 7 days of placebo and then either naproxen or placebo (crossed over from period 1) as their second period of dosing.
In each study, animals underwent a baseline period of dosing, where each animal was dosed once daily orally with vehicle by gavage.
The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study.
Similar(53)
If this is not possible, then patient exposure might be reduced by shorter periods of dosing or alternative routes of administration.
Although a number of studies examined the period of PND10 15, the choice of dosing periods in the present studies was variable, and, to date, there has not been a systematic evaluation of potentially sensitive developmental periods.
This was followed by a 12-week period of dose titration, making a total of 16 weeks of treatment.
Treatment interruptions, if they occur, must be short and followed by a strict period of dose taking.
Therefore, the findings would suggest that the most critical period of dose limiting diarrhea with L-CAP is during the first few cycle of therapy.
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