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5 16 17 18 For each patient, we identified a period of continuous use of spironolactone beginning with the first prescription for spironolactone after the patient's 66th birthday.
For each patient, we defined a period of continuous use of each statin based on successive refills of prescriptions for the same statin within 1.5 times the duration of the preceding prescription.
First, drug holidays anecdotally have been used to counteract waning effectiveness after a period of continuous use; perhaps by interrupting the development of possible tolerance and/or the need to continually increase the dose over time.
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Longer periods of continuous use were associated with much higher levels of prescribed opioids (Table 1).
Probabilities of continuous use and medication free periods were assessed for the total population and stratified according to new use.
Despite patients being informed of continuous use of the sensor throughout the study period, only 34 patients followed the protocol.
Previous users are "survivors" of the early period of pharmacotherapy and are likely to have a higher probability of continuous use [ 23].
Subjects whose last run out date in a series of continuous use was within 60 days of the end of the study period were considered continuous users of therapy with no evidence of discontinuation.
The story did not report allegations of continuous use nor cite the age 15".
Survival probabilities of continuous use are usually assessed, assuming that at the end of observation, patients were either continuous users of medication during the preceding period of follow-up or not [ 19].
The probabilities of continuous use, the refilling of at least one ICS prescription in each year of follow-up, and medication free periods were assessed by Markov analysis.
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