Suggestions(2)
Exact(6)
In 1992, the U.K. Department of Health issued a recommendation that 400 μg of folic acid per day should be taken during the periconceptional period: before conception and throughout the first 12 weeks of pregnancy.
Onset of pregnancy is clinically defined as the first day of the ovulatory cycle in which the pregnancy was conceived; this may correspond to the first day of the last menstrual period before conception in women with regular menstrual cycles.
The periconceptional period (before conception and up to 12 wk of gestation) is arguably the optimal exposure window for nutritional interventions because it encompasses several critical gestational processes including implantation and placentation (6).
L P-value for linear trend Should bread be fortified at the proposed level, more than two-thirds of women would fail to achieve the intended folic acid intake of 140 μg/d in the period before conception.
We used the FFQ from the Women's Health Initiative Clinical Trial (17) to assess maternal dietary intake during the 3-month period (before conception and during the first trimester).
Methods: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected on day 10 after the first day of the last menstrual period before conception occurred (n = 128) and during the previous cycle (if any, n = 111).
Similar(54)
Class et al. have reported that preconceptional stress increased the risk of infant mortality, which indicated the period immediately before conception may be a sensitive developmental period [ 42].
Nonhormonal contraceptive methods per se are unlikely to be protective against hypospadias, but women employing them should have less exposure to exogenous hormones in the period just before conception than those who become pregnant immediately after stopping oral contraceptive use or while still using oral contraceptives.
Table 1 shows the distribution of the preceding IPIs for all pregnancies in our sample and for second-order and higher-order pregnancies in the MCH FP area for which we have data on the date of the last menstrual period before the conception.
Residential histories were collected for the period 3 months before conception through pregnancy, including the month/year that the mother started and stopped living in each location.
This was followed by identification of which product was used and when (which months during the period 3 months before conception to birth, and in which years after birth).
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