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Nutrient deficiency during perinatal development is associated with an increased risk to develop obesity, diabetes and hypertension in the adulthood.
Malrotation in children is due to either an incomplete or non-rotation of the foetal mid-gut during perinatal development.
Here, we review 34 studies in rodents linking the availability of choline during gestation and perinatal development to neurological function or performance of offspring in cognitive and behavioral tests.
This indicates that protein deficiency during the critical period of perinatal development programs the circadian clock.
Additional morphometric analysis during embryonic and perinatal development showed that islet composition is also altered in Hnf6 Tg mice.
Similarly, this information will be critical for the study of perinatal development and organogenesis by providing a more definitive total GL.
Notably, exposure to nutrient restriction during perinatal development results in offspring which are hyperphagic and exhibit enhanced preference for high-fat food [11], [12], [13], [14].
Given the importance of intrauterine programming and BAT in energy balance, our findings implicate new roles for the lactogens in the interface between fetal and perinatal development and metabolic disease.
A number of quantitative or semi-quantitative RT-PCR analyses have been conducted to investigate transcriptional changes in the hypothalamus after nutrient restriction during the critical period of perinatal development.
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NFAT4, in particular, is an important transcription factor in perinatal lung development and maturation [13].
In this review we highlight some novel processes of perinatal immune development that both contribute to the immunotoxic vulnerability of the developing immune system and cannot be effectively examined via current adult-exposure assessment.
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