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ESCRT complexes dissociate from the perimeter membrane of endosomes before inward vesiculation occurs through the activity of the ATPase, Vps4.
This would be expected if it was directed to the perimeter membrane of MVBs rather than to luminal vesicles.
CHMPs are likely to multimerise to form a flat lattice on the perimeter membrane of the endosome [ 11,12 ].
Components needed for inward and outward budding of the MVB perimeter membrane to generate intralumenal vesicles and recycling tubules, respectively, have begun to be identified.
DO has been shown to enhance the incorporation of DO/DM complexes and MHCII into the perimeter membrane of MVBs fostering interaction of these molecules without their degradation.
Many lysosomally directed membrane proteins are sorted onto intralumenal vesicles, whilst recycling proteins remain on the perimeter membrane from where they are removed via tubular extensions.
Similar(54)
The mechanism through which mutations in ATP13A2 cause KRS is not fully understood, although it has been previously shown that the wild-type protein is located in the perimeter lysosomal membrane of transiently transfected cells, while the unstable truncated mutants are retained in the endoplasmic reticulum and degraded by the proteasome (4).
Epithelium parameters are expressed as a percentage of the airway basement membrane perimeter.
Airway layers are presented as area (μm) corrected by the basement membrane perimeter (μm).
Airways were classified by their basement membrane perimeter (large > 1,500 µm, medium > 1,000 µm, small < 1,000 µm).
In some samples, staining was very strong around the entire CT membrane perimeter, while staining was limited to regions bordering with the ST in others.
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