We do not rule out that DNA methylation changes in other one-carbon metabolism genes or planar cell polarity genes may be contributing, perhaps in interaction with DNA methylation changes in folate transport genes, to an increased NTD risk, but we are filling a significant data gap on T-DMRs in folate transport genes.
The observed conformational differences may thus serve to regulate the exposure of the aromatic patch, and the conservation of the patch suggests that it is important, perhaps in interactions with regulatory ligands or with other regions of the full TRPV4 homotetramer.
Collectively these data support further studies to determine if Tn-C actively participates in the development of bronchiolar obliteration in DA induced BO, perhaps through interactions with the epithelium or fibroblasts.
Multiple factors, perhaps including increased interactions with the healthcare system due to comorbidity, might contribute to this finding.
The leader peptides are better conserved than the core peptides, perhaps indicating the involvement of the leader peptide in interactions with biosynthesis proteins [ 42].
The vulnerability of the retina in the mouse model may suggest a differential role of Wdr36 in the two species, perhaps through interaction with different retina-specific molecules.
The constitutively active mutant Irga6-K82A retained many interactions in Y2H including, perhaps surprisingly, the interaction with Irgm3 (see next section) but lost bi-directionality in its interaction with WT Irga6 and interaction with Irgb6 was completely abolished.
On the basis of this convergent evidence, we hypothesized that the gene that codes for NDEL1 (NDElocatedted on chromosome 17p13.1) may be involved in the pathophysiology of SZ, perhaps via interaction with DISC1.
The department doesn't want you involved in any physical interaction with the inmates.
Cdc42 has an important role in cell polarity, perhaps through its interaction with APC and actin at the leading edge [19].
