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Because of the genetic background difference, it cannot be ruled out that the Mesoamerican population is more vulnerable to the effect of certain, perhaps deleterious, EFHC1 alleles.
Observational studies like our own cannot answer this question, yet interventional studies suggest that while anemia is bad, correcting it not necessarily helpful and perhaps, deleterious [ 3, 8].
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Perhaps more deleterious to the Eagles, the Philadelphia defensive and offensive players bickered after the game because the Eagles could not score a touchdown from the 1-yard line despite seven attempts.
The angiotensin-converting enzyme (ACE) deletion (D) variant is associated with greater ACE activity and perhaps with deleterious cardiorespiratory pathophysiological responses.
Perhaps the deleterious effect of rhodopsin mis-trafficking is offset by the beneficial effect of rhodopsin expression in the rho−/− retina.
The lack of specificity of the proto-mRNA, however, would also have enhanced the production of ser-gly and ser-ser, perhaps with deleterious effects on the cell.
Nonetheless, cisatracurium administration, although perhaps less deleterious than rocuronium [ 59, 60], should still be used with care in patients undergoing long-term MV (that is, >48 hours), as the risk of VIDD is likely to be increased.
Such molecular targets might also be difficult to use therapeutically, because agents that acted like TTP, or increased TTP's ability to destabilize TNF-α mRNA, might be expected to have similar effects on the GM-CSF mRNA in other cell types, perhaps with deleterious effects on GM-CSF functions.
Most of the mutations will be deleterious.
It evokes unpleasant images, and is always deleterious.
The Fujian strain also emerged from a low frequency clade as discussed above but, perhaps, because of deleterious mutations elsewhere in the genome, it was not initially dominant.
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