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Actinomycin D is used in combination with melphalan in isolated limb perfusion in the treatment of patients with melanoma in-transit metastases and is well known to augment tumour cell sensitivity towards tumour necrosis factor alpha in vitro.
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Because of the importance of preservation of intestinal perfusion in the early treatment of sepsis and septic shock, early F XIII administration might be considered in septic patients but requires clinical approval.
In multivariate regression analysis, which included age, ulceration and thickness of the primary, and the treatment variable of perfusion, age (P=.02) and perfusion for the treatment of recurrence (P=.006) were significant predictors of survival.
Isolated limb perfusion (ILP) provides an excellent tool in the treatment of locally advanced tumours.
Isolated limb perfusion (ILP) with chemotherapy alone has uniformly failed in the treatment of irresectable extremity soft tissue sarcomas.
We report our experience in the treatment of patients with twin-reversed arterial perfusion (TRAP) sequence using radiofrequency ablation to stop perfusion to the acardiac twin and protect the pump twin.
The primary goal in the treatment of patients with shock is to restore the tissue perfusion and oxygenation.
This is because we had to limit the time period of the SITS data to before there was use of perfusion CT in the treatment selection process at some of the Australian centres.
They suggested that these findings may explain the early cerebral perfusion pressure-independent decrease in CBF after SAH and therefore microarterial constrictions and microthrombosis may serve as novel targets for the treatment of early perfusion deficits after SAH.
Hence, statins should be effective for the treatment of diabetic skin ulcers by increasing blood perfusion to the tissues.
These experimental and clinical results consistently demonstrate that there is a place for treatment of abnormal perfusion in the context of early severe sepsis and septic shock.
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